CB2 immunoreactivity was noted in 35% of human breast cancer tissues [127] while CB2 receptors were expressed in a variety of breast cancer cell lines (T-47D, MCF-7, MDA-MB-231, MDA-MD-468, EVSA-T, and SkBr3) and human breast tissues as determined by Western blot, RT-PCR, and/or immunofluorescence techniques [69, 103, 127, 129, 130]. This evidence concerns the gene CNR2 and breast carcinoma.