In addition, expression of CB2 is induced following the oral administration of specific Lactobacillus strains in colonic epithelial cells, through the NF-κB pathway [102], whilst it has been reported that CB1 receptor expression in human colon cancer was induced by 17β-oestradiol through an oestrogen-receptor-dependent mechanism [103]. The gene discussed is CNR2; the disease is malignant colon neoplasm.