In the pregnant mouse uterus, it has also been reported to downregulate FAAH activity [112], and when taken together with reduced NAPE-PLD expression in mice these data suggest that the NAPE-PLD  : FAAH activity ratio in the mouse uterus may be key to the regulation of local AEA levels and thus maintenance of pregnancy or endometrial pathologies, such as cancer. Here, GPLD1 is linked to cancer.