As expected, the control cells did not form macro-metastases at all, but in contrast the tumor cells that have been exposed to TNFα + Estrogen + EGF stimulation have given rise to macro-metastases in 38% of the animals (Figures 10(a2), 10(b), and 10(c)), as determined in 2 independent experimental repeats showing similar results. This evidence concerns the gene EGF and neoplasm.