In addition, in response to the combined stimulation by TNFα + Estrogen + EGF, the tumor cells have acquired the ability to produce high levels of functional matrix metalloproteinase 9 (MMP9; Figure 8(c)), a key enzyme in degradation of the extracellular matrix (ECM) during local invasion end extravasation of the tumor cells [82]. This evidence concerns the gene EGF and neoplasm.