Along these lines, we and others have shown that TNFα was highly expressed in breast tumors [22–25], that the incidence of TNFα expression was significantly increased in advanced stages of breast cancer (detected in approximately 90% of the patients with recurrent disease) [22], and that TNFα induced EMT and invasion of breast tumor cells [22, 26, 27]. The gene discussed is TNF; the disease is breast neoplasm.