As a result of TNFα + Estrogen + EGF stimulation, new cell subtypes have dominated the tumor cell population, expressing high levels of VLA6 and of the metastasis-related adhesion molecules CD44 and β1, accompanied by high levels of CXCL8, CCL2, and MMPs that were released by the cells. The gene discussed is CXCL8; the disease is neoplasm.