CCL2 and neoplasm: Doing a “per cell” analysis, we found that the stimulation of the tumor cells by TNFα + Estrogen + EGF has given rise to potent elevation in the release of the inflammatory chemokines CXCL8 (Figure 8(b1)) and CCL2 (Figure 8(b2)), which have been well characterized as strong tumor-promoting factors by virtue of their potent angiogenic activities and recruitment of tumor-supporting leukocytes to the tumors [76–81].