CYBB and ischemia reperfusion injury: Overproduction of reactive oxidative species (ROS) by NADPH oxidase is generally considered to play a critical role in the pathogenesis of ischemia reperfusion injury, and there are a number of NADPH homologs, such as Nox1, Nox2 (also named as gp91phox), and Nox3-4 [31].