Others include Dusp6, Pou3f1, Klf5, Calcoco1, and Ppargc1α. Interestingly, Ppargc1α is up-regulated, contrary to what would be anticipated by studies in Huntington disease models in which cortical BDNF, striatal TrkB, and Ppargc1α are all down-regulated (reviewed in [27]). This evidence concerns the gene DUSP6 and juvenile Huntington disease.