Few DNA methylation studies have been reported for NSCLC, and the DNA methylated genes identified in these were APC, CDH13, CDKN2A, DAPK, hMLH1, HOX, OTX1, HOX2, ZIC4, and RASSF1[24,27,29,30]. This evidence concerns the gene OTX1 and non-small cell lung carcinoma.