SPMIP5 and Familial prostate cancer: In Stage III chromosome, 10 was identified with nine hypermethylated genes and these were: LBX1, NKX6-2, PTF1A, SLC18A3, SORC3, SPAG6, C10orf26, and C10orf82. The ladybird homeobox 1 (LBX1) gene has been associated with the breakpoint regions involved in T-cell leukemia [92] and methylated in prostate cancer [93].