Deletion of the IKKε gene rendered mice partially resistant to weight gain, insulin resistance, steatosis and the long-term inflammation produced by high fat diet (Chiang et al., 2009), and administration of the dual specificity IKKε/TBK1 inhibitor amlexanox to diet-induced obese or ob/ob mice produced even more profound effects (Reilly et al., 2013). The gene discussed is TBK1; the disease is steatosis.