Interestingly, the tumor with the highest level of GLI1 expression (tumor ID TCGA-AA-3715) harbored a missense mutation in PTCH1 (P681L; c.2042C>T) that was identical to a confirmed somatic alteration previously identified in a basal cell carcinoma [6] (Fig, panel B). This evidence concerns the gene PTCH1 and basal cell carcinoma.