Pinelliae rhizome and Citrus reticulata and their combinational prescription have deep inhibitory effects on airway inflammation in a murine model of asthma and it was mediated by suppression of Th2 cytokines (IL-4, IL-5, IL-13), IgE, eosinophil CCR3 expression in lung [21]. The gene discussed is IL5; the disease is asthma.