CDH1 and breast cancer: Indeed, the set of genes which gained H3K27me3 is related to genes down-regulated in a previously described CDH1 knockdown model of EMT [30] (Figure 4A) and to genes with low expression in basal-like as compared to luminal-like breast cancer cell lines [32] (P <0.0001; Figure 4B; Table S6 in Additional file 1).