Strikingly, the same interplay between H3K4me3 and H3K27me3 occurs for master genes involved in the EMT process, such as PDGFRα, which is essential for Twist1 to promote tumor metastasis via invadopodia [34], and the splicing regulator ESRP1, which is repressed by Snail1 to promote EMT [35] (Table S5 in Additional file 1). Here, PDGFRA is linked to neoplasm.