The chromosomal translocation of mastermind-like gene family (MAML2) located on chromosome 11q21 with the N-terminal cAMP response element-binding protein (CREB) binding domain of CREB-regulated transcription coactivator 1 (CRTC1) at 19q21 has been shown to be a highly specific translocation in mucoepidermoid carcinomas of the salivary gland [19]. The gene discussed is CRTC1; the disease is salivary gland mucoepidermoid carcinoma.