TLR2 and infection: Importantly, TLR2-deficient (TLR2-/-) mice infected with Bb possess up to 100-fold higher bacterial loads than wild-type mice in different tissues at both early and late times post-infection, even though these TLR2-/- mice produced Bb-specific antibodies at similar levels and of similar Bb-antigen specificity as infected wild-type mice [21,30].