Other mAb combinations, including anti-CTLA4/PD-1, anti-CTLA4/PD-1/CD40, anti-CTLA4/PD-1/TIM-3, anti-CTLA4/PD-1/LAG-3 and anti-CTLA4/PD-1/LAG-3/CD40 had no effect on tumor growth. The gene discussed is LAG3; the disease is neoplasm.