NOTCH3 and non-small cell lung carcinoma: In our previous study, we found that lithium chloride (LiCl), which inhibited glycogen synthase kinase 3β (GSK-3β) activity in vivo and vitro, and mimicked the biochemical effect of Wnt signaling by leading to stabilization of β-catenin protein, up-regulated Notch3 signaling, and Notch3 siRNA weakened the effects of LiCl on the cell cycle of NSCLC cell lines [14].