Moreover, it has been demonstrated that overexpression of GAPDH is sufficient to protect chronic myelogenous leukemia (CML) cells from imatinib-induced caspase-independent cell death and knockdown of GAPDH resensitizes cells to imatinib-induced cell death [41]. This evidence concerns the gene GAPDH and chronic myelogenous leukemia, BCR-ABL1 positive.