However, we noticed that expressing FLT3/ITD or FLT3/D835Y did not affect the SAHA-inhibited the nuclear formation of RAD51/γ-H2A.X co-foci in irradiated TF1 cells, indicating that SAHA can suppress HDR in response to IR in AML cells where NHEJ is already compromised by expression of these FLT3 mutants (Figure 5D). This evidence concerns the gene FLT3 and acute myeloid leukemia.