Meanwhile, the expression of Sox2, Oct4 and Nanog in HeLa/TSA cells was reduced significantly after LV-UbBsi infection (Figure 4E, F), and the SP+ ratio of HeLa/TSA-LV-UbBsi cells was significantly reduced from 2.58% to 1.25% (p<0.01) (Figure 4G). The gene discussed is POU5F1; the disease is infection.