ESR1 and breast carcinoma: In the 50 whole section areas of 24 breast carcinomas with increased copy number, the average ESR1 copy number was 4.55 (range 2.30-12.05) pre- and 4.44 (range: 2.10-13.70) post-RNase (p=0.47) and the average ESR1/CEP6 ratio was 2.16 (range 1.28-6.89) pre- and 1.98 (range 1.13-5.37) post-RNase (p=0.006).