TNS1 and acute myeloid leukemia: PR domain-containing 16 gene (PRDM16) is a known oncogene implicated in acute myeloid leukaemia (AML) and osteosarcoma [42,43] Tensin 1 gene (TNS1) is the only gene present in the relevant FMCR, and TNS1 overexpression in vitro was previously shown to significantly promote cell migration in fibroblasts [44].