Furthermore, details of specific kinetic steps in the chemomechanical cycle and operation of the six-component system are very likely to be changed somewhat by replacing non-human myosins with human β-cardiac myosin, and HCM- and DCM-causing mutations are expected to induce very small changes in such parameters, resulting in the diseased state. The gene discussed is MYH14; the disease is familial dilated cardiomyopathy.