We have found that (i) PSGL-1 expressed by F508del leukocytes was engaged during transmigration of PSGL-1+ leukocytes [16–17] (Figure 5 A) in LPS-induced lung inflammation; (ii) blockade of PSGL-1 prevented thrombocytopenia (Figure 5 B) and reduced transmigration of neutrophils to the alveoli (Figure 5 D). Here, SELPLG is linked to Thrombocytopenia.