In vivo studies in both rat and mice models have proved that diosgenin rich extracts from D. bulbifera play the most significant role in antioxidant activity by upregulating antioxidant enzyme activities like total superoxide dismutase (SOD), peroxidase and catalase leading to cardioprotection by reducing lipid peroxidation, myocardial infarction as well as myocardial ischemic reperfusion injury [49], [50]. This evidence concerns the gene SOD1 and myocardial infarction.