These findings suggest that, although CCND1 gene amplification may be a potential prognostic biomarker for RFS, it may not be a good predictive biomarker for adjuvant tamoxifen benefit or lack thereof in these high-risk pre-menopausal women, and should not be used as a predictive biomarker for tamoxifen in this group of breast cancer patients until other large clinical trial cohorts are examined. Here, CCND1 is linked to breast carcinoma.