PAK1 and breast neoplasm: Since it has been shown that 11q13 amplification is frequently associated with contiguous or distinct amplification of the neighboring 11q14 region, and that this region contains a candidate tamoxifen-resistance gene, p21-activated kinase-1 (PAK1) [6], we verified the presence of 11q14 amplification in an in-house array CGH dataset of 90 breast tumors.