NOS2 and neoplasm: As shown in Fig. 8, the calculated tumor volumes on day 28 were 300±136 (mm3 ± SD) and 163±91 in the NOS2 and NOS2TR control groups and 55±60 and 104±66 in the NOS2 and NOS2TR groups treated with NEAPP-AM, respectively (p = 0.0014 and 0.097, respectively).