One oft-cited potential exception is the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) study of patients with congestive heart failure, which failed to show improvements in cardiovascular outcomes in patients with acute heart failure (AHF) treated with the vasopressin type 2 receptor (V2R) antagonist, tolvaptan, versus placebo [97]. Here, AVPR2 is linked to congestive heart failure.