In summary, we identified a new fungal drimane sesquiterpene lactone, SF002-96-1, which inhibits survivin expression by blocking the binding of critical transcription factors (Stat3, NF-κB) to the promoter of the survivin gene and triggers apoptosis in the colon carcinoma cell line Colo 320. The gene discussed is STAT3; the disease is colon carcinoma.