However, Xiangshao granule treatment remarkably rescued the decrease in the body weight (P < 0.05), increased crossings in the open field test (P < 0.05), upregulated the expression of hippocampal BDNF and TrkB expression, and reduced the serum CRH, CORT, and ACTH concentrations compared with the depression group (P < 0.05). The gene discussed is CORT; the disease is major depressive disorder.