In conclusion, the results offered in the present study for evaluation of sFlt-1 and PlGF concentrations in midtrimester settled and supported the concept that an imbalance in circulating angiogenic and antiangiogenic factors was concomitant with the potential of preeclampsia development and that variation in circulating levels of these particular markers (sFlt-1 and PlGF) preceded the commencement of clinical features of the disease. The gene discussed is PGF; the disease is preeclampsia.