BRAF and colorectal cancer: Correlation of aberrant methylation and oncogene mutation are also reported in colorectal cancer; high-methylation and intermediate-methylation epigenotypes strongly correlated to BRAF mutation and KRAS mutation, respectively, and low-methylation epigenotype strongly correlated to lack of oncogene mutation (Shen et al., 2007; Yagi et al., 2010; Hinoue et al., 2012).