RASSF1A (Ras association (RalGDS/AF-6) domain family member 1) is methylated in 20% of papillary thyroid cancer, leading to activation of the RAS-MAPK (Mitogen-Activated Protein Kinase) signal (Xing et al., 2004). The gene discussed is RASSF1; the disease is thyroid gland papillary carcinoma.