Strong evidence supports an etiologic role of NLRP1 in various autoimmune diseases, since NLRP1 variants have been associated with an increased susceptibility for Addison’s disease, type 1 diabetes, Alzheimer’s disease, celiac disease, Kawasaki disease, autoimmune thyroid disease, generalized vitiligo, systemic sclerosis, and rheumatoid arthritis (198–204). This evidence concerns the gene NLRP1 and Alzheimer disease.