NLRP6 and infection: Rather than contributing to elimination of infections, NLRP6 has a deleterious role within the hematopoietic and the non-hematopoietic compartments and, accordingly, NLRP6−/− mice show increased resistance to infection by extracellular E. coli, intracellular L. monocytogenes and S. typhimurium, and display increased circulatory monocytes and neutrophils upon infection (148).