Thus, NLRP3 and NLRP6 appear to have a specific protective role within the gastrointestinal tract through production of IL-18, and accordingly, NLRP3−/− and NLRP6−/− mice are more susceptible to colon inflammation and colon cancer (142, 143, 145, 146). Here, NLRP6 is linked to malignant colon neoplasm.