Reduction of nuclear DNMT1 levels was observed in postmortem brain samples from PD patients and in the brains of α-synuclein transgenic mice, underlying a mechanism in which DNMT1 might be excluded from the nucleus by α-synuclein, and the segregation of DNMT1 further resulted in hypomethylated CpG islands upstream of α-synuclein(Desplats et al., 2011). Here, SNCA is linked to Parkinson disease.