The UCHL1 promoter was found hypermethylated in diverse types of cancer (Kagara et al., 2008; Yu et al., 2008), however, analysis of UCHL1 promoter in the hippocampus and frontal cortex of PD patients and controls displayed no significant differences in CpG methylation between these two groups (Barrachina and Ferrer, 2009). This evidence concerns the gene UCHL1 and Parkinson disease.