A large-scale sequencing analysis of postmortem brain samples identified methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci, suggesting that some other PD-related genes could also be epigenetically modified in PD brains (Plagnol et al., 2011). This evidence concerns the gene GPNMB and Parkinson disease.