P2RX3 and migraine disorder: Thus, the migraine mediator CGRP not only largely increases the amplitude of P2X3 currents generated in nociceptive trigeminal neurons, but it also significantly speeds up recovery from desensitization via an intracellular kinase-dependent process of P2X3 receptor phosphorylation (Fabbretti et al., 2006; Giniatullin et al., 2008).