In a recent work it was found that TDP43 and fused in sarcoma/translated in liposarcoma (FUS/TLS), which are proteins that regulate RNA processing and have been found to be mutated in some cases of ALS, interact with each other forming a ribonucleoprotein complex that regulates the expression of HDAC6 through its mRNA stability (Kim et al., 2010). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.