DGCR8 and schizophrenia: Interestingly, restoration of IGF2 expression in the hippocampus rescued the observed spatial working memory deficits in Dgcr8+/- mice, suggesting that IGF2 contributes – at least in part – to the learning and spatial working memory deficits that are associated with 22q11.2DS-related schizophrenia (Ouchi et al., 2013).