The list of 213 candidates contained many known T-ALL driver genes (Figure 3), such as NOTCH1, BCL11B, FBXW7, IL7R, JAK1 and JAK3; and it also contained the drivers CNOT3 and RPL10, recently identified in our exome re-sequencing study [17]; and CTCF, which was recently reported to be recurrently mutated in ETP-ALL [13]. Here, JAK3 is linked to acute lymphoblastic leukemia.