Remarkably, by simply selecting all genes having a candidate somatic mutation in at least two samples (213 genes in total), we already achieved a highly significant enrichment for T-ALL related genes, such as NOTCH1, BCL11B, FBXW7, DNM2, JAK3, JAK1, and IL7R. Among the remaining candidates we searched for additional evidence and we propose seven additional candidate drivers because they are either “functionally similar” to the previously known drivers, or because they were mutated somatically at least once in another T-ALL cohort [17], or both. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.