The T-ALL genome is mainly characterized by the over-expression of TF, such as TLX1/3 and TAL1, in combination with gain-of-function NOTCH1 mutations, and with additional mutations in chromatin modifiers, cellular signaling factors such as those involved in the JAK-STAT signaling pathway [57], tumor suppressor genes (TP53, PTEN, WT1), or in other genes such as ribosomal genes [17]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.