NOTCH1 and acute lymphoblastic leukemia: In addition, point mutations and small insertions/deletions (INDELs) have also been described leading to oncogenic events, such as mutations activating NOTCH1 that occur in more than 60% of T-ALL cases [10], or mutations in cytokine receptors and tyrosine kinases such as IL7R and JAK3[11]–[17].