ZFYVE26 and neurodegenerative disease: Importantly, analysis of different brain structures at 2 months of age did not reveal any differences between genotypes, thus brain development appears not to be grossly impaired by disruption of Zfyve26. In line with a neurodegenerative disease, the brain size was significantly reduced in the knockout cohort at 16 months of age (Fig. 4A–C), when knockout mice displayed severe motor deficits.