In the zebrafish Mm model, the early treatment window of DMOG (treatment between -4 hpi and 24 hpi, followed by wash-off then bacterial burden assessment at 4 dpi) and the DA hif-1αb RNA injection at the one-cell stage, (an effect that will be diluted as the embryo develops), indicate that Hif-1α stabilization at early stages of Mm infection, pre-granuloma formation, is causing the decrease bacterial burden at 4 dpi. The gene discussed is HIF1A; the disease is infection.