The current study was the first study to measure gene expression levels and protein concentrations of visfatin/Nampt, vaspin, and RBP-4 in liver, muscle, subcutaneous, omental, and mesenteric adipose tissues and their protein concentrations in plasma and to investigate the relationship between insulin resistance and their expression in blood and tissues in morbidly obese subjects. Here, RBP4 is linked to Insulin resistance.