Presently, as non-invasive methods for diagnosing fibrosis in patients with chronic viral hepatitis C, such as fibroscan or elastometry, gradually replace liver biopsy, performing this procedure with a view to analyzing IFI27, SOCS3 and miR-122 expression for the prognosis of EVR is not associated with additional benefits. Here, SOCS3 is linked to chronic hepatitis C virus infection.