LRP2 is a member of the low-density lipoprotein receptor [LDLR (MIM606945)] gene family, and two SNPs of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia [2] and Alzheimer’s disease [3], respectively. The gene discussed is LRP2; the disease is early-onset autosomal dominant Alzheimer disease.