Active GSK3β (Y216) phosphorylates and activates SRC family kinases that induce nuclear exclusion and ubiquitin-mediated degradation of NRF2 through its phosphorylation of Y568 (40,41); iii) activation of EGFR by EGF lead to induction of NRF2 in non-small cell lung cancer cells (18); and iv) phosphorylation of NRF2 serine 40 by PKCδ is required for stabilization and nuclear localization of NRF2 (42). Here, NFE2L2 is linked to non-small cell lung carcinoma.