To investigate whether immunization of the mice with HSP105-derived peptides causes autoimmunity, HLA-A2 Tgm were immunized with the HSP105 A2-7 and A2-12 peptides emulsified in incomplete Freund’s adjuvant at 7-day intervals and then sacrificed 7 days after the second vaccination. The gene discussed is HSPH1; the disease is Autoimmunity.