NOS2 and hepatocellular carcinoma: They further reported that the increased oxidative stress, apoptosis and mitochondrial dysfunction in human hepatoma (HepG2) cells might be associated with altered NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells, a protein complex that controls the transcription of DNA found in all animal cell types and is involved in cellular response to stimuli, free radicals, oxidized LDL, bacterial or viral antigens) based cell signaling as STZ increases the expression of iNOS (inducible nitric oxide synthase) and translocation of NF-κBp65 (RelA) transcription factor to the nucleus.