Overexpression of 14-3-3 θ reduces dopaminergic cell death in cultured neurons exposed to rotenone and 1-methyl-4-phenylpyridinium (MPP+) and this effect was dependent on binding to Bax, supporting the idea that 14-3-3 proteins are antiapoptotic and may be targeted to promote neuronal survival in PD [56]. The gene discussed is YWHAQ; the disease is Parkinson disease.