Recently, it was demonstrated that long term (12 weeks) administration of RTA dh404 resulted in attenuation of oxidative stress, inflammation, and fibrosis in the remnant kidneys of rats with CKD induced by 5/6 nephrectomy, which was accompanied by a reduction in proteinuria and mean arterial pressure; induction or rescue of Nrf2 and its target genes, and decreased activation and expression of NF-κB and its target genes in kidney tissue were also observed (Aminzadeh et al., [11], Xenobiotica, in press). This evidence concerns the gene NFKB1 and chronic kidney disease.