In the idiopathic nerve, the highest number of RAGE-positive fibers costained for CML, ∼90.69 ± 0.4%, followed by HMGB1, ∼76.80 ± 7.38%, and mDia1, ∼66.83 ± 4.23%, while in the diabetic nerve, ∼90.18 ± 0.13% of RAGE-positive fibers stained for CML, ∼81.75 ± 2.63% stained for mDia1, and ∼73.14 ± 5.51% stained for HMGB1 (Fig. 3B). The gene discussed is DIAPH1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.