On the contrary, CML is thought to be one of the key molecules in the inflammatory, RAGE-NF-κB-dependent pathway in diabetes, but also, independently from RAGE, it plays an important role in cumulative oxidative stress-induced neuronal changes, (Haslbeck et al. 2007), contributing to the pathogenesis of neuropathy. This evidence concerns the gene NFKB1 and diabetes mellitus.