Extensive study of CML expression in different types of peripheral neuropathies (Haslbeck et al. 2007) revealed that increased oxidative stress and/or CML-RAGE-NF-κB-activated pathway likely plays a role in diabetes, vitamin B12 deficiency related and chronic inflammatory demyelinating peripheral neuropathy, however, the authors did not observe either RAGE or CML increase in the idiopathic neuropathy. This evidence concerns the gene NFKB1 and vitamin B12 deficiency.