AGER and diabetes mellitus: Extensive study of CML expression in different types of peripheral neuropathies (Haslbeck et al. 2007) revealed that increased oxidative stress and/or CML-RAGE-NF-κB-activated pathway likely plays a role in diabetes, vitamin B12 deficiency related and chronic inflammatory demyelinating peripheral neuropathy, however, the authors did not observe either RAGE or CML increase in the idiopathic neuropathy.