Extensive study of CML expression in different types of peripheral neuropathies (Haslbeck et al. 2007) revealed that increased oxidative stress and/or CML-RAGE-NF-κB-activated pathway likely plays a role in diabetes, vitamin B12 deficiency related and chronic inflammatory demyelinating peripheral neuropathy, however, the authors did not observe either RAGE or CML increase in the idiopathic neuropathy. The gene discussed is AGER; the disease is vitamin B12 deficiency.