Our results revealed that in the control nerve, ∼29.8 ± 2.5% of all NF-positive fibers stained for RAGE, whereas in the idiopathic and diabetic nerve, the number of all NF-positive fibers stained for RAGE was higher, ∼48.9 ± 5.5% and ∼40.8 ± 4.4, respectively. The gene discussed is AGER; the disease is diabetes mellitus.