On the contrary, CML is thought to be one of the key molecules in the inflammatory, RAGE-NF-κB-dependent pathway in diabetes, but also, independently from RAGE, it plays an important role in cumulative oxidative stress-induced neuronal changes, (Haslbeck et al. 2007), contributing to the pathogenesis of neuropathy. The gene discussed is AGER; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.