Sickle Cell Disease (SCD) is the most common genetic disorder of haemoglobin in sub-Saharan Africa.1,2 In Africa it is estimated that about 200,000 children are born with the disease annually.3 A point mutation on the 6th codon of the beta-globin gene located on the short arm of chromosome 11 produces a defective beta globin chain, which under low oxygen tension polymerizes into long fibres that eventually lead to abnormally deformed (sickled) red cell. Here, HBB is linked to hereditary disease.