Sickle Cell Disease (SCD) is the most common genetic disorder of haemoglobin in sub-Saharan Africa.1,2 In Africa it is estimated that about 200,000 children are born with the disease annually.3 A point mutation on the 6th codon of the beta-globin gene located on the short arm of chromosome 11 produces a defective beta globin chain, which under low oxygen tension polymerizes into long fibres that eventually lead to abnormally deformed (sickled) red cell. This evidence concerns the gene HBB and sickle cell disease.