Children had less severe disease at ART initiation in later years for almost all markers – baseline CD4%/count increased and there were significant declines in the proportions with severe immunosuppression (81 to 63%; p<0.001), WHO Stage III/IV disease (75 to 62%; p<0.001) and severe anemia (12 to 7%; p<0.001) (Figure 3; Supplementary Table S2 in File S1). This evidence concerns the gene CD4 and anemia (phenotype).