PFKFB3 and neoplasm: It is generally considered that the glycolysis mechanism induced by TIGAR bears close similarity to that of the bisphosphatase (FBPase) domain of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFK-2/FBPase-2), in that TIGAR expression leads to a reduction in fructose-2, 6-bisphosphate (Fru-2, 6-BP) levels, thereby suppressing glycolytic flux and tumor growth.