Although it has been reported that HA-CD44 signaling promotes the progression of several cancers, such as breast cancer [25], colorectal carcinoma [17], fibrosarcoma [26], and glioblastoma multiforme [27], in this study we found that CD44 was overexpressed in both normal tissue and PTC tissue and overexpression of CD44 was not relevant to progression of PTC. This evidence concerns the gene CD44 and cancer.