Tumor growth was substantially inhibited in TLR4-KD and CXCR7-KD group in contrast to scrambled siRNA group in the presence of LMW-HA (Figure 4(b)), suggesting that LMW-HA may promote growth of W3-derived PTC model tumors in vivo through TLR4/CXCR7 pathway. This evidence concerns the gene ACKR3 and neoplasm.