ART4 and hepatocellular carcinoma: The cell lines HepG-2 and A549 have been selected as models, because the former is well known for expressing ASGP-R [25, 26], which is present only on hepatocytes at a high density and retained on several human hepatoma cell lines, that binds and internalizes galactose-terminal (asialo)glycoprotein [27–29], and the latter one was taken as contrast agent which has no ASGP-R.